JoinCaring Co., Ltd.
Vision
JoinCaring was established in 2020, focusing on the microbial resource and production technology development of edible and medicinal fungi and probiotics. We produce high-quality raw materials rich in mycochemicals or polysaccharides which can be used to manufacture functional health foods or as active pharmaceutical ingredients (APIs) for new drug development.
Management Team
Although we are a start-up company, our team members have more than 30 years of experience in the research and development of microbial production process including strain improvement, submerged fermentation process (liquid fermentation) , solid state fermentation process and mushroom cultivation (fungal fruiting body). Our team is composed of three PhDs and three masters in the field of life sciences from Taiwan's top universities. We are skillful in the culture of various microorganisms and the application of products, including probiotics, microfungi and macrofungi (mushrooms) and their bioactive compounds. In addition, based on the friendship with our team members, many famous scholars serve as academic consultants, which allows us to establish an AI (active innovation) operating style.
Products
I. Fruiting body of Cordyceps militaris
1. About Cordyceps militaris
Cordyceps militaris, commonly known as the caterpillar fungus, is a valuable edible and medicinal fungus and a substitute for Ophiocordyceps sinensis (Cordyceps sinensis, dong-chong-xia-cao, DongChongXiaCao). Modern pharmaceutical research has found that the types and contents of mycochemicals such as cordycepin, mannitol and cordyxanthins in Cordyceps militaris are much more than those in Ophiocordyceps sinensis. Compared with dongchongxiacao, which is rare, expensive and may contain too much harmful elements such as arsenic, Cordyceps militaris might has more valuable medicinal functions.
2. Fruiting body of Cordyceps militaris
It is generally believed that Cordyceps militaris fruiting bodies contain higher pharmaceutical nutrients than mycelia. Although it is feasible to produce Cordyceps militaris fruiting bodies using insect pupae as substrates, the cost is high and the quality is difficult to control. Commercial production usually uses grain-based substrates such as rice, barley or Job's tears to grow Cordyceps militaris, so vegetarians can also eat its fruiting bodies. Cordyceps militaris must be illuminated by white or blue light to form rod-shaped, orange fruiting bodies. The technique of producing fruiting bodies is not difficult, but Cordyceps militaris strain can easily degenerated. To produce Cordyceps militaris fruiting bodies with consistent quality, technicians with professional mushroom cultivation techniques are needed.
3. Function of Cordyceps militaris
Cordyceps militaris is well known within the realm of traditional Chinese medicine. Its anti-inflammatory, anti-tumor, anti-aging properties and other bioactivities have been well documented. The medicinal properties of Cordyceps militaris can be attributed to a number of mycochemicals, including cordycepin, cordymin, mannitol, polysaccharide and many other compounds. Cordycepin is a nucleoside analogue of adenosine, differing only in a single hydroxyl group. The biological activity of cordycepin has been demonstrateds in several clinical trials and various scientific reports. It has been shown to induce apoptosis, reduce inflammation, and inhibit RNA transcription in cell cultures. For these reasons, it is being studied for its anti-cancer metastasis properties. Recently, it has been reported that extracts containing cordylutenes (formerly known as cordyxanthins and cordycepene) protect the eye (macula) from damage caused by LED blue light.
The promising effects of Cordyceps militaris on overall health are expected to make it important in the medical field and in daily diets.
4. Cordyceps militaris fruiting body produced by Joincaring
Joincaring produces high-quality Cordyceps militaris fruiting bodies that can be used in health foods, as well as bioactive metabolites that can be used as active pharmaceutical ingredients (APIs) for new drug development. Joincaring's Cordyceps militaris fruiting body material is extremely valuable and contains high concentrations of cordycepin (over 1.5%) and cordylutenes.
5. Supply of Cordyceps militaris fruiting body and bioactive compounds
Please contact Carrie Chang
joincaring@accurome.com
joincaring@gmail.com
II. Tiger Milk Mushroom (Lignosus rhinocerus, Lignosus rhinocerotis)
1. About Tiger Milk Mushroom （Lignosus rhinocerus, Lignosus rhinocerotis）
Lignosus rhinocerus (Lignosus rhinocerotis), commonly known as "tiger milk mushroom, TMM", is a valuable edible and medicinal fungus with a variety of therapeutic effects. Species in the genus Lignosus (such as Tiger Milk Mushroom) is mainly distributed in subtropical or tropical rainforest areas, such as Taiwan, Malaysia, Thailand, Indonesia, Philippines, Papua New Guinea and southern China. The indigenous people of Malaysia call "tiger milk mushroom" as "Cendawan Susu Rimau". It is traditionally used for health care and is known as the national treasure of Malaysia. Its importance is comparable to that of niu-chang-chih (Antrodia cinnamomea or Taiwanofungus camphoratus) in Taiwan, Meshimakobu (Phellinus linteus or Sanghuangporus sanghuang) in Japan and South Korea, dong-chong-xia-cao (Ophiocordyceps sinensis or Cordyceps sinensis) in China, Chaga mushroom (Inonotus obliquus) in high latitude countries, and globally important Cordyceps militaris and Lingzhi (Ganoderma lucidum and relatives).
2. Sclerotia of Tiger Milk Mushroom （Lignosus rhinocerus）
The fruiting body of Tiger Milk Mushroom is composed of sclerotium (buried underground), stipe and pileus. In the forest, sclerotia are difficult to be discovered unless the stipe and pileus emerge from the sclerotium in subsoil under appropriate enviromental conditions. Although the sclerotia buried in the ground can be preserved for many years without deterioration, the growth process of the stipe and pileus will consume the efficacy of tiger milk mushroom sclerotium. In order to obtain effective tiger milk mushroom functional materials, it is necessary to artificially cultivate pure strains of Lignosus rhinocerus to produce authentic sclerotia and block the formation of mushroom stipe and pileus, which requires very specialized technology.
3. Function of Tiger Milk Mushroom （Lignosus rhinocerus）
As early as 1664, there was a report mentioned that Southeast Asian aborigines used "tiger milk mushroom" to treat coughs, asthma, bronchitis, vomiting, fever, nose allergies, food poisoning and other illnesses or as a tonic to strengthen the body. Currently, researchers continue to use modern technology to verify the theoretical mechanism of its efficacy. Research shows that sclerotia of Lignosus rhinocerus contains a variety of bioactive components such as polysaccharides, polysaccharide-protein complexes (PSPC) and mycochemicals, which have significant anti-inflammatory, antioxidant, anti-proliferative and immunomodulatory effects. The anti-inflammatory effects may be related to the use of Lignosus rhinocerus sclerotia to treat coughs, asthma, nose and skin allergies, chronic hepatitis or lung disease. In addition, the dietary fiber in Lignosus rhinocerus sclerotia can promote the growth of probiotics Bifidobacterium longum and Levilactobacillus brevis in the intestine, so it has the potential to be developed into a prebiotic for intestinal care.
4. Tiger Milk Mushroom （Lignosus rhinocerus）sclerotia produced by Joincaring
In 2021, R&D team of JoinCaring collected multiple fungal sclerotia and fresh mushroom tissues from low-altitude mountainous areas in Taiwan, and isolated pure cultures for further research. By molecular DNA sequence analysis and morphological identification, it was confirmed that some of the pure fungal isolates were Lignosus rhinocerus.
After in-depth research and development, Joincaring has successfully grown authentic tiger milk mushroom sclerotia in a factory with controlled environmental factors and established a standard production process. This allows us to produce and provide adequate quantities of tiger milk mushroom sclerotia for various utilization.
5. Supply of Tiger Milk Mushroom （Lignosus rhinocerus）Sclerotia
Please contact Carrie Chang
joincaring@accurome.com
joincaring@gmail.com
III. Wulingshen (sclerotium of Xylaria nigripes and relatives)
1. What is Wulingshen (Wu-Ling-Shen)?
Wulingshen, a kind of fungal sclerotia, was originally reported in the Chengdu Plain in western Sichuan of China for medicinal purposes. Xylaria nigripes is commonly connected to these massive sclerotia produced within abandoned underground macrotermitine termite nests. Recent research has shown that at least six species of Xylaria such as Xylaria nigripes, Xylaria subescharoidea, Xylaria neonigripes and Xylaria rogersionigripes can form Wulingshen.
2. Function of Wulingshen
As a traditional Chinese medicine, wild-collected Wulingshen has the effects of eliminating dampness, tranquillizing the mind, stopping heart palpitations, promoting lactation, tonifying kidney, and promoting sleep. Currently, the fermented mycelia of Xylaria nigripes and its relatives are dried into powder and made into capsules with the trade name "Wuling Capsule". According to the 2020 edition of the "Pharmacopoeia of the People's Republic of China". "Wuling Capsule" has the effects of sedating and hypnosis, improving cognition, regulating neurotransmitters, anti-depressant, improving hearing, and anti-radiation. It is mainly used clinically to treat insomnia, or combined with other drugs to treat anxiety, depression symptoms and sleep disorders caused by various diseases such as cardiovascular and cerebrovascular diseases, gynecological diseases, digestive diseases, ear and throat diseases, etc.
3. Wulingshen and mycelial powder of Xylaria nigripes and its relatives
After intensive research and development, JoinCaring successfully cultivated authentic Wulingshen sclerotia and functional mycelial powder of Xylaria nigripes and its relatives. under controlled environmental factors in the laboratory, and established a standard production process. This allows us to produce sufficient quantities of Wulingshen sclerotia and functional mycelial powder of Xylaria nigripes and its relatives for scientific research and clinical trials.
4. Supply of Wulingshen and mycelial powder of Xylaria spp.
Please contact Carrie Chang
joincaring@accurome.com
joincaring@gmail.com